[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"blog-post-improving-production-efficiency-by-controlling-protozoa-via-herbal-blend-en":3,"blog-related-improving-production-efficiency-by-controlling-protozoa-via-herbal-blend-en":62,"blog-popular-single-en":249,"blog-categories-single-en":393,"blog-tags-single-en":430,"responsive-image-[object Object]":13,"blog-section-posts-en":502,"menu-navbar-en":506,"social-links-en":691,"menu-footer-en":712,"available-locales":839},{"data":4},{"id":5,"title":6,"slug":7,"alternate_slugs":8,"summary":9,"content":10,"meta_title":11,"meta_description":12,"focus_keyword":13,"featured_image":14,"thumbnail_image":35,"published_at":50,"category":51,"categories":55,"tags":57},62,"Improving production efficiency by controlling protozoa via herbal blend","improving-production-efficiency-by-controlling-protozoa-via-herbal-blend",{"en":7},"The continuous improvement of production efficiency in industrial poultry farming still remains an element that is likely to be improved by different factors related to the animals’ management, nutrition, genetics, and state of health.","\n\u003Cp>The continuous improvement of production efficiency in industrial poultry farming still remains an element that is likely to be improved by different factors related to the animals’ management, nutrition, genetics, and state of health.\u003C\u002Fp>\n\n\n\n\u003Cp>Being able to reduce the incidence of some pathologies that diminish the husbandry performance of our productions has turned into a critical factor in the usual routine of the production management of our poultry-raising business. Among these pathologies, coccidiosis is regarded as the leading cause of decreased productive yields in the planet, not only due to the losses that the disease’s clinical presentation can entail but also, and with greater relevance: sub-optimal growth, pigmentation deficiency, deteriorating food conversion brought about by the subclinical presentation of this parasitic pathology.\u003C\u002Fp>\n\n\n\n\u003Cp>Seven species are acknowledged to affect poultry production, as each species produces medical conditions with a particular location in the intestinal tract (Allen and Fetterer 2002).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Coccidiosis\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>The parasite multiplies in the gastrointestinal tract, causing tissue damage with the subsequent stoppage of a proper absorption of nutrients, dehydration, haemorrhaging, loss of pigmentation and increased susceptibility to other pathogens. (McDougald and Fitz-Coy, 2008).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Controlling coccidiosis\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Despite the considerable research conducted on coccidiosis in poultry, infection by these protozoa remains a major problem in intensive poultry production. Improvements in handling, use of vaccines and other practices have helped control coccidia infections; however, traditionally, the most commonly-used means of control has involved the use of anti-coccidian medication.\u003C\u002Fp>\n\n\n\n\u003Cp>With the prohibition of antimicrobial agents in some countries, less effectiveness of some medications due to resistance development and the growing disapproval of antibiotic use by consumers, producers have started looking for alternative treatments.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Natural anti-coccidian compounds\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Natural anti-coccidian compounds found in plants comprise an obvious alternative, having shown encouraging results. Plant compounds such as Acacia concinna and Saccharum oicinarum, have been widely and historically studied and utilised.\u003C\u002Fp>\n\n\n\n\u003Cp>Because this kind of product contains only natural plants – dried and ground –, it can be ensured that these are safe products, suited for use both in conventional production and organic production, not subject to limited or regulated concessions for their inclusion. There are no limitations to the amounts used, either regarding feeding times – that is, it can be used at every stage of growth –, allowing it to be used with other synthetic anti-coccidians – rotation programmes – and with coccidia vaccines. Research and field studies conducted on a product containing these plants have allowed observing the benefits provided in terms of improving the productive parameters in poultry by controlling the protozoal parasitic load, as this acts in the intestinal environment of poultry and as a promoter of a greater immunity in terms of antibody production.\u003C\u002Fp>\n\n\n\n\u003Cp>Because the mode of action of anti-coccidian compounds occurs using various natural compounds acting in a broad and complex manner, interacting synergistically, it is unlikely to lead to the mentioned parasites’ developing a resistance.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>How does this association work?\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Plants contain many compounds – called secondary metabolites – which these can use for their own purposes – metabolism, defence, etc.–. When they are ingested by animals, such as poultry, these compounds can have effects on the animal’s metabolism.\u003Cbr>Many of the synthetic products currently in use were created from observing compounds present in plants, which were isolated and then synthesised in order to reproduce the effects of natural products.\u003C\u002Fp>\n\n\n\n\u003Cp>Unlike a synthetic drug with just one single action mechanism, the metabolites active in the plants can be manifold and act together synergistically, which could make it difficult to determine exactly the mode of action.\u003C\u002Fp>\n\n\n\n\u003Cp>This mixture’s saponin content allows modifying the membranes of coccidia organisms and otocysts produced for coccidia proliferation.\u003C\u002Fp>\n\n\n\n\u003Cp>Anamika et al. 2017 examined Acacia concinna and found that it contained 11.8% of saponins. The main biological effect of saponins has been attributed to its action on the membranes, where it has the ability to form pores.\u003C\u002Fp>\n\n\n\n\u003Cp>In particular, the saponins’ ability to bond with the cholesterol of the protozoan cell membrane can modify the membrane’s function and structure and account for its anti-coccidian activity. Natural saponins can inhibit protozoa development by interacting with the cholesterol present in the parasite’s cell membrane (Wang et al., 1998).\u003Cbr>It appears that, after the parasite invasion, free radicals, together with high levels of nitrous oxide production, comprise the main factors that compromise the cells’ antioxidant defence system.\u003C\u002Fp>\n\n\n\n\u003Cp>Compounds meeting the requirements of the antioxidant defence system or interfering directly with free radicals, such as tannins, can restore the balance of oxidants\u002Fantioxidants, which leads to improved intestinal integrity and yield during subclinical coccidiosis (Cejas et al., 2011).\u003C\u002Fp>\n\n\n\n\u003Cp>Although this plant mixture’s saponin and tannin content appears to provide the main mode of action for controlling coccidia, it should also be pointed out that Saccharum oicinarum also provides an additional benefit through an immunostimulating effect.\u003C\u002Fp>\n\n\n\n\u003Cp>S. oicinarum can improve protective immunity against coccidiosis (Awais et al., 2011) as shown in the studies. Sugar cane extract contains a polysaccharide that activates the route to supplementing the immune system, boosting the immune response to coccidia (El-Abasy et al., 2003).\u003C\u002Fp>\n\n\n\n\u003Cp>Saccharum oicinarum is rich in phenolic compounds that have been shown to comprise antioxidant and anti-inflammatory activities, as well as inhibitory effects on the sporulation of otocysts (Abbas et al., 2015).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Tests\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Research tests have shown that the mixture of these plants can be just as effective a means in controlling coccidia infections as the currently admissible synthetic coccidiostats.\u003C\u002Fp>\n\n\n\n\u003Cp>This year, a test was conducted using 300 one-day-old chicks, distributed into 5 groups. Each group comprised 6 sub-groups with 10 chicks, in the testing area for animal parasitology (Servicapa, Mexico).\u003C\u002Fp>\n\n\n\n\u003Cp>The purpose was to evaluate the anti-coccidial efficacy of the previously described herbal blend, in two different doses (500g\u002Ft and 750g\u002Ft) relative to the efficacy of one of the Ionophores in greatest demand in the poultry community (Salinomicina 12%), challenged with an inoculation of sporulated oocysts of isolated coccidia mixed on day 21.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Doses\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>In doses of inoculation, per chick, of:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\u003Cli>E. acervulina 100,000 oocysts\u003C\u002Fli>\u003Cli>E. maxima 50,000 oocysts\u003C\u002Fli>\u003Cli>E. tenella 50,000 oocysts\u003C\u002Fli>\u003C\u002Ful>\n\n\n\n\u003Cp>The inoculation was administered orally and, at 35 days, the anti-coccidial efficacy was determined based on the Injury Rate (IR) Oocyst Rate (OR) via sampling and analysis of stools at 7 and 14 days post-infection, using the Johnson & Reid method. The 2 groups with herbal blends (T3 and T4) confirm their efficacy by presenting a lower IR in the three intestinal regions relative to the injuries of the group treated with Salinomycin (T5).\u003C\u002Fp>\n\n\n\n\u003Cp>The results of the anticoccidial efficacy – IAC – of the herbal blend, in the two evaluated doses, shows very interesting results. This parameter interrelates via the following equation:\u003C\u002Fp>\n\n\n\n\u003Cp>IAC = (%S + %GPR) – (IR + OR)\u003C\u002Fp>\n\n\n\n\u003Cp>The survival, the relative weight gain and the injury and oocyte rates – Ma et al., 2011–, obtaining the rating for low anti-coccidian activity when the score is below 160; moderate when in the 160-180 range, and good when the calculation is over 180 (Morisawa et al. 1977).\u003C\u002Fp>\n\n\n\n\u003Cp>We can see that the figures for both groups with herbal blend somewhat exceed 180, with which it can be concluded that their anti-coccidian activity would be good and comparable to that of the products of non-natural origin.\u003C\u002Fp>\n\n\n\n\u003Cp>It can be concluded that natural products containing Acacia concinna and Saccharum oicinarum are reliable and can provide protection against common coccidia infections while promoting intestinal integrity and balance, and improving immunological functions. It is important to prove product efficacy and profitability by conducting tests as shown here, with a view to controlling and reducing the decline in production efficiency caused by this type of pathology.\u003C\u002Fp>\n","Improving production efficiency by controlling protozoa via herbal blend - Nuproxa Switzerland Ltd","",null,{"id":15,"filename":16,"path":17,"url":18,"alt_text":19,"title":13,"width":20,"height":21,"webp_url":22,"optimized_url":22,"thumbnail_url":23,"srcset":24,"srcset_webp":25,"responsive_images":26,"processing_status":34},757,"HEADER (4).png","assets\u002F2026\u002F04\u002Fheader-4-69e269792197a.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-4-69e269792197a.png","Gut microbiota illustrated in detail, Nuproxa intestinal health and 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nipple drinker early poultry phase gut health Nuproxa animal nutrition brooding","Improving production efficiency by controlling protozoa via herbal blend (thumb)",349,230,"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387.png 349w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd11d0a0a-c707-4bbc-b7ee-b9c59deaf387.webp 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challenges in poultry production. This intestinal disease, caused by protozoa of the genus \u003Cem>Eimeria\u003C\u002Fem> spp., affects the performance and health of poultry, resulting in considerable economic losses.\u003C\u002Fp>\u003Cp>Faced with this problem, producers are seeking natural and effective alternatives to maintain their birds' intestinal health without resorting to conventional options.\u003C\u002Fp>\u003Ch2>Challenges of coccidiosis and the role of anticoccidials\u003C\u002Fh2>\u003Cp>\u003Cstrong>Coccidiosis\u003C\u002Fstrong> causes severe damage to the intestinal epithelium, affecting nutrient absorption and weakening the birds' immune system. If left uncontrolled, it can cause:\u003C\u002Fp>\u003Cul>\u003Cli>\u003Cp>Reduced growth and body weight;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Increased feed conversion ratios (FCR);\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>High mortality in cases of severe outbreaks.\u003C\u002Fp>\u003C\u002Fli>\u003C\u002Ful>\u003Cp>\u003Cstrong>Synthetic anticoccidials\u003C\u002Fstrong> play an important role in controlling coccidiosis, but they present challenges that encourage the search for \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcoccidiosis-reduction-combined-strategies\u002F\">alternative solutions\u003C\u002Fa> focused on intestinal integrity and performance. These solutions help prevent and control the effects of \u003Cem>Eimeria\u003C\u002Fem> spp., minimizing damage to the intestinal tract and improving the birds' overall performance.\u003C\u002Fp>\u003Cp>The choice of the appropriate \u003Cstrong>anticoccidial\u003C\u002Fstrong> depends on the management strategy adopted by each producer, with a focus on maintaining long-term efficacy and preventing resistance. However, the trend toward safer and more sustainable solutions has driven the use of products based on phytochemicals, which optimize intestinal health naturally and efficiently.\u003C\u002Fp>\u003Ch2>Anticoccidials: factors affecting their effectiveness in poultry production\u003C\u002Fh2>\u003Cp>The use of \u003Cstrong>anticoccidials\u003C\u002Fstrong> is one of the most common strategies for \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcoccidiosis-treatment\u002F\">controlling coccidiosis in poultry production\u003C\u002Fa>. However, several factors can compromise their effectiveness and performance. From dosing issues to resistance due to prolonged use, it is essential to understand how to optimize the use of these products.\u003C\u002Fp>\u003Cp>\u003Cstrong>In our detailed blog post, we explore five key factors that affect the efficiency of anticoccidial drugs and how to overcome these challenges:\u003C\u002Fstrong>\u003C\u002Fp>\u003Cul>\u003Cli>\u003Cp>Causes of anticoccidial compound toxicity;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Use of ionophores and nicarbazin;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Development of resistance in coccidia;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Loss of drug sensitivity;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Sanitary conditions and farm management.\u003C\u002Fp>\u003C\u002Fli>\u003C\u002Ful>\u003Cp>Learn more about these factors and access our exclusive material with practical recommendations to maximize \u003Cstrong>coccidiosis control\u003C\u002Fstrong>.\u003C\u002Fp>\u003Cp>\u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fanticoccidial-medications\">\u003Cstrong>[Read the full blog post here]\u003C\u002Fstrong>\u003C\u002Fa>\u003C\u002Fp>\u003Ch2>A smart solution for intestinal health and performance support\u003C\u002Fh2>\u003Cp>NuxaSan™ is a state-of-the-art polyherbal solution that offers a natural, effective, and smart solution to help address challenges related to gut welfare. Its exclusive formulation combines Ayurvedic wisdom with modern science, providing unmatched benefits that support avian gut health.\u003C\u002Fp>\u003Ch3>Key benefits of the phytocompounds found on NuxaSan™\u003C\u002Fh3>\u003Cul>\u003Cli>\u003Cp>\u003Cstrong>Integrity:\u003C\u002Fstrong> Thanks to its rich composition of selected phytocompounds (saponins and tannins), it helps maintain intestinal health and contributes to the natural and effective management of problems of the gut environment during challenges.\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cstrong>Optimized poultry performance:\u003C\u002Fstrong> It helps maintain zootechnical performance in challenging situations by contributing to the maintenance of the intestinal wall and improvement of nutrient absorption.\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cstrong>Contributing to antioxidant function and gut welfare:\u003C\u002Fstrong> Tannins and saponins are known to contribute to host immunity and antioxidant function, promoting better intestinal resilience.\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cstrong>Certified safety and quality:\u003C\u002Fstrong> NuxaSan™ is a safe, residue-free solution manufactured under Nuproxa's globally recognized, certified feed safety management system, ensuring unparalleled quality for the poultry industry.\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>\u003Cstrong>Vibrant pigmentation:\u003C\u002Fstrong> It contributes to skin and yolk pigmentation, improving the visual quality of the final products.\u003C\u002Fp>\u003C\u002Fli>\u003C\u002Ful>\u003Ch2>Why choose natural solutions for Gut Health?\u003C\u002Fh2>\u003Cp>In a market that prioritizes food safety and sustainability, natural solutions, such as NuxaSan™, stand out for delivering effective results without compromising the health of the end consumer or animal welfare. Furthermore, the absence of unwanted residues allows for its safe use in multi-species food production facilities.\u003C\u002Fp>\u003Ch2>Tangible results: the impact of NuxaSan™ on poultry production\u003C\u002Fh2>\u003Cp>Producing healthy poultry requires an integrated approach that includes quality nutrition and optimization of the gut microbiota. The phytocompounds in NuxaSan™ contribute significantly to:\u003C\u002Fp>\u003Cul>\u003Cli>\u003Cp>Improved nutrient absorption;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Supporting the gut under challenges;\u003C\u002Fp>\u003C\u002Fli>\u003Cli>\u003Cp>Stronger, more productive birds with a balanced and resilient digestive system.\u003C\u002Fp>\u003C\u002Fli>\u003C\u002Ful>\u003Ch2>Optimize your birds' gut health with NuxaSan™\u003C\u002Fh2>\u003Cp>If you want to tackle intestinal \u003Cstrong>challenges\u003C\u002Fstrong> in a smart, natural, safe, and efficient way, NuxaSan™ is the ideal solution. Support your birds' performance and take your poultry production to the next level.\u003C\u002Fp>\u003Cp>\u003Cstrong>Talk to one of our Nuproxa experts and discover how NuxaSan™ can transform your business!\u003C\u002Fstrong>\u003C\u002Fp>","Smart Natural Solutions for Poultry Gut Integrity","anticoccidials",{"id":74,"filename":75,"path":76,"url":77,"alt_text":78,"title":12,"width":20,"height":21,"webp_url":79,"optimized_url":79,"thumbnail_url":80,"srcset":81,"srcset_webp":82,"responsive_images":83,"processing_status":34},785,"01KVRKGCBKECQ279T6F0DJ0998.png","gallery\u002F01KVRKGCBKECQ279T6F0DJ0998.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998.png","Coccidiosis: solutions for poultry production","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-small.png 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-medium.png 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-large.png 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998.png 1728w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-small.webp 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-medium.webp 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-large.webp 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998.webp 1728w",{"thumbnail":80,"thumbnail_webp":84,"small":85,"small_webp":86,"medium":87,"medium_webp":88,"large":89,"large_webp":90},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-thumbnail.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-small.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-small.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-medium.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-medium.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-large.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKGCBKECQ279T6F0DJ0998-large.webp",{"id":92,"filename":93,"path":94,"url":95,"alt_text":96,"title":12,"width":97,"height":98,"webp_url":99,"optimized_url":99,"thumbnail_url":100,"srcset":101,"srcset_webp":102,"responsive_images":103,"processing_status":34},784,"01KVRKD3BKXEN0QXZRRC1H4MQS.png","gallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS.png","Natural solutions for coccidiosis",350,250,"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS.png 350w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS.webp 350w",{"thumbnail":100,"thumbnail_webp":104},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVRKD3BKXEN0QXZRRC1H4MQS-thumbnail.webp","2026-06-23T02:48:27+00:00",{"id":52,"name":53,"slug":54,"description":13},[108],{"id":52,"name":53,"slug":54,"description":13},[],{"id":111,"title":112,"slug":113,"alternate_slugs":114,"summary":115,"content":116,"meta_title":117,"meta_description":118,"focus_keyword":12,"featured_image":119,"thumbnail_image":137,"published_at":151,"category":152,"categories":153,"tags":155},131,"5 factors affecting the efficiency of anticoccidial medications in poultry production","anticoccidial-medications",{"en":113},"Control of coccidiosis is one of the greatest challenges in modern poultry production. Although anticoccidial medications are effective tools, several factors can directly impact their efficiency, ranging from resistance issues to management and dosing conditions. With this in mi...","\u003Cp>\u003Cstrong>Control of coccidiosis\u003C\u002Fstrong> is one of the greatest challenges in modern \u003Cstrong>poultry production\u003C\u002Fstrong>. Although \u003Cstrong>anticoccidial medications\u003C\u002Fstrong> are effective tools, several factors can directly impact their efficiency, ranging from resistance issues to management and dosing conditions.\u003C\u002Fp>\u003Cp>With this in mind, Nuproxa has developed a series of content aimed at guiding industry professionals on best practices and care in the use of these products. In previous articles, we explored the fundamentals and treatment methods for coccidiosis. Check them out:\u003C\u002Fp>\u003Cp>\u003Ca target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcoccidiosis-in-poultry\u002F\">Coccidiosis in poultry: an ongoing challenge in poultry farming\u003C\u002Fa> \u003Cbr>\u003Ca target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcoccidiosis-treatment\u002F\">Guide to the prevention and treatment of coccidiosis in poultry: part 1\u003C\u002Fa> \u003Cbr>\u003Ca target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcoccidiosis-reduction-combined-strategies\u002F\">Combined and natural strategies to reduce the risk of coccidiosis in poultry\u003C\u002Fa>\u003C\u002Fp>\u003Cp>In this blog post, we will address five factors that directly affect the effectiveness of anticoccidial medications.\u003C\u002Fp>\u003Ch2>\u003Cstrong>1. Causes of intoxication by anticoccidial compounds\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>Improper use or incorrect dosing of these compounds can lead to animal intoxication, affecting their development and performance (Novilla, 1992; Frigg et al., 1983). Causes include the inappropriate selection of medication for the production phase or undesirable interactions with other medications.\u003C\u002Fp>\u003Ch2>\u003Cstrong>2. Use of ionophores and nicarbazin\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>Ionophore anticoccidials are widely used but require caution, as improper dosing can result in toxicity. (Novilla, 1992). Nicarbazin is widely used and often included in rotation programs with other products to reduce adverse effects (Ryley & Betts, 1973; Mathis & McDougald, 1982).\u003C\u002Fp>\u003Ch2>\u003Cstrong>3. Development of resistance by coccidia\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>Resistance occurs when a medication is used repeatedly without rotation with other products. (Vertommen & Peek, 1994). This is a common issue in the industry, and the rotation of anticoccidials is recommended to reduce the risk.\u003C\u002Fp>\u003Ch2>\u003Cstrong>4. Loss of sensitivity to the medication\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>Resistance develops when continuous administration or prolonged exposure to the same anticoccidial makes coccidia less sensitive to the medication (Ruff, 1993). This highlights the importance of the conscious and diversified use of these products.\u003C\u002Fp>\u003Ch2>\u003Cstrong>5. Farm conditions and risks for broilers\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>Sanitary and management conditions on farms directly affect bird health and the effectiveness of medications (Graat et al., 1996; Henken, 1994). In farms with hygiene issues, the risk of subclinical coccidiosis is high, silently affecting bird performance.\u003C\u002Fp>\u003Ch3>\u003Cstrong>Conclusion\u003C\u002Fstrong>\u003C\u002Fh3>\u003Cp>In this context, it is necessary to understand the characteristics of \u003Cstrong>anticoccidial products\u003C\u002Fstrong>, their molecules, mechanisms of action, levels of toxicity, the different species of \u003Cstrong>\u003Cem>Eimeria\u003C\u002Fem>\u003C\u002Fstrong>, and the correct way to use them, ensuring results without compromising animal performance.\u003C\u002Fp>\u003Cp>To support this analysis in practice, you can rely on Nuproxa technical support. Through the \u003Cstrong>Gut and Hepatic Health Program (GHP)\u003C\u002Fstrong>, the team conducts field diagnostics, laboratory analyses, and continuous monitoring, generating data that support more confident decision-making in \u003Cstrong>poultry production\u003C\u002Fstrong>.\u003C\u002Fp>\u003Cp>Based on this information, it is possible to assess intestinal health, adjust nutritional strategies, and improve productive performance with greater predictability.\u003C\u002Fp>\u003Cp>\u003Cstrong>Contact Nuproxa to learn more: \u003C\u002Fstrong>\u003Ca target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcontact\">https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcontact\u003C\u002Fa>\u003C\u002Fp>\u003Ch3> \u003Cbr>\u003Cstrong>References:\u003C\u002Fstrong>\u003C\u002Fh3>\u003Cp>Novilla, M. N. (1992). \u003Cem>The veterinary importance of the toxic syndrome induced by ionophores\u003C\u002Fem>. Veterinary and Human Toxicology, 34(1), 66–70.\u003C\u002Fp>\u003Cp>Frigg, M., Broz, J., & Weber, G. (1983). \u003Cem>Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics in broiler chicks\u003C\u002Fem>. Archiv für Geflügelkunde, 47(5), 213–220.\u003C\u002Fp>\u003Cp>Ryley, J. F., & Betts, M. J. (1973). \u003Cem>Chemotherapy of chicken coccidiosis\u003C\u002Fem>. Advances in Pharmacology and Chemotherapy, 11, 221–293.\u003C\u002Fp>\u003Cp>Mathis, G. F., & McDougald, L. R. (1982). \u003Cem>Drug responsiveness of field isolates of chicken coccidia\u003C\u002Fem>. Poultry Science, 61, 38–45.\u003C\u002Fp>\u003Cp>Vertommen, M. H., & Peek, H. W. (1994). \u003Cem>How can we break resistance problems?\u003C\u002Fem> World Poultry, Special Supplement on Coccidiosis.\u003C\u002Fp>\u003Cp>Ruff, M. D. (1993). \u003Cem>The value of sensitivity testing in avian coccidiosis\u003C\u002Fem>. Avicultura Profesional, 10(3), 109–116.\u003C\u002Fp>\u003Cp>Graat, E. A. M. I. (1996). \u003Cem>Effects of initial litter contamination level with Eimeria acervulina on population dynamics and production characteristics in broilers\u003C\u002Fem>. Veterinary Parasitology, 165, 223–232.\u003C\u002Fp>\u003Cp>Henken, A. M. (1994). \u003Cem>Description of a simulation model for the population dynamics of Eimeria acervulina infection in broilers\u003C\u002Fem>. Parasitology, 108, 503–512.\u003C\u002Fp>\u003Cp>Williams, R. B. (1999). \u003Cem>A compartmentalised model for the estimation of the cost of coccidiosis to the world’s chicken production industry\u003C\u002Fem>. International Journal for Parasitology, 29, 1209–1229.\u003C\u002Fp>","5 factors affecting anticoccidial efficiency in poultry","Control of coccidiosis is one of the greatest challenges in modern poultry production. Although anticoccidial medications are effective tools, several factors c",{"id":120,"filename":121,"path":122,"url":123,"alt_text":12,"title":124,"width":20,"height":21,"webp_url":125,"optimized_url":125,"thumbnail_url":126,"srcset":127,"srcset_webp":128,"responsive_images":129,"processing_status":34},783,"01KVGP3M0P2K6MSADFAQJRA6G8.png","gallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8.png","Galpão de criação de frangos de corte com centenas de aves brancas sobre piso coberto de maravalha, alimentadores tubulares amarelos distribuídos em linhas e tubulações metálicas ao longo do ambiente.","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-small.png 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-medium.png 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-large.png 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8.png 1728w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-small.webp 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-medium.webp 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-large.webp 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8.webp 1728w",{"thumbnail":126,"thumbnail_webp":130,"small":131,"small_webp":132,"medium":133,"medium_webp":134,"large":135,"large_webp":136},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-thumbnail.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-small.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-small.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-medium.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-medium.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-large.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVGP3M0P2K6MSADFAQJRA6G8-large.webp",{"id":138,"filename":139,"path":140,"url":141,"alt_text":142,"title":13,"width":143,"height":144,"webp_url":145,"optimized_url":145,"thumbnail_url":146,"srcset":147,"srcset_webp":148,"responsive_images":149,"processing_status":34},770,"SM38_NUP_Thumb-300x214.png","assets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89.png","Close-up of a white chicken in a poultry farm, illustrating coccidiosis control",300,214,"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89.png 300w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89.webp 300w",{"thumbnail":146,"thumbnail_webp":150},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fsm38-nup-thumb-f5bc705f2c89-thumbnail.webp","2026-04-24T22:12:31+00:00",{"id":52,"name":53,"slug":54,"description":13},[154],{"id":52,"name":53,"slug":54,"description":13},[],{"id":157,"title":158,"slug":159,"alternate_slugs":160,"summary":161,"content":162,"meta_title":163,"meta_description":164,"focus_keyword":13,"featured_image":165,"thumbnail_image":182,"published_at":195,"category":196,"categories":197,"tags":199},34,"Natu-B4®: 22 years of innovation in natural choline with scientific validation","natural-choline-natu-b4",{"en":159},"The evolution of animal nutrition in recent decades has been marked by a constant search for production efficiency, safety, and sustainability. In this scenario, choline has established itself as a strategic nutrient, mainly due to its role in energy and lipid metabolism. Over the years, what has changed is the approach adopted to meet this nutritional demand.  From the outset, Nuproxa approach to the development of […]","\n\u003Cp>The evolution of \u003Cstrong>animal nutrition \u003C\u002Fstrong>in recent decades has been marked by a constant search for production efficiency, safety, and sustainability. In this scenario, choline has established itself as a strategic nutrient, mainly due to its role in \u003Cstrong>energy and lipid metabolism\u003C\u002Fstrong>. Over the years, what has changed is the approach adopted to meet this \u003Cstrong>nutritional demand\u003C\u002Fstrong>. \u003Cbr> \u003Cbr>From the outset, Nuproxa approach to the development of Natu-B4® focused on understanding and scientifically proving how a \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fpolyherbal-products\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">\u003Cstrong>polyherbal solution\u003C\u002Fstrong>\u003C\u002Fa> could act more broadly on animal metabolism, going beyond simply replacing synthetic \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fnatural-alternative-choline-chloride\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">\u003Cstrong>choline chloride\u003C\u002Fstrong>.\u003C\u002Fa>  \u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-a-scientifically-based-polyherbal-innovation-nbsp\">\u003Cstrong>A scientifically based polyherbal innovation\u003C\u002Fstrong> \u003C\u002Fh2>\n\n\n\n\u003Cp id=\"h-a-scientifically-based-polyherbal-innovation-natu-b4-is-formulated-from-carefully-selected-plants-used-in-their-natural-form-without-chemical-extractions-among-the-species-used-are-solanum-nigrum-and-achyranthes-aspera-which-provide-natural-phospholipid-conjugates-such-as-phosphatidylcholine-in-addition-to-other-bioactive-compounds-characteristic-of-the-plant-matrix\">\u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fproducts\u002Fnatu-b4\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">\u003Cstrong>Natu-B4®\u003C\u002Fstrong>\u003C\u002Fa> is formulated from carefully selected plants, used in their natural form, without chemical extractions. Among the species used are \u003Cem>Solanum nigrum \u003C\u002Fem>and \u003Cem>Achyranthes aspera\u003C\u002Fem>, which provide natural phospholipid conjugates, such as phosphatidylcholine, in addition to other bioactive compounds characteristic of the plant matrix.  \u003C\u002Fp>\n\n\n\n\u003Cp>Over more than 22 years of development, the product has been evaluated in more than 100 \u003Cem>in vivo \u003C\u002Fem>studies conducted at universities, research centers, and commercial facilities, involving more than 10 animal species.   \u003C\u002Fp>\n\n\n\n\u003Cp>This data set has resulted in the largest, \u003Cstrong>most diverse, and most complete scientific dossier in the natural choline segment\u003C\u002Fstrong>, reinforcing its position as the most validated solution on the market. \u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-why-is-scientific-validation-a-distinguishing-feature-of-natural-choline-nbsp\">\u003Cstrong>Why is scientific validation a distinguishing feature of natural choline?\u003C\u002Fstrong> \u003C\u002Fh2>\n\n\n\n\u003Cp>One of \u003Cstrong>Natu-B4®\u003C\u002Fstrong>‘s most significant milestones is the \u003Cstrong>scientific proof\u003C\u002Fstrong> that supports its mode of action.   \u003C\u002Fp>\n\n\n\n\u003Cp>Studies described in Nuproxa technical materials show that the natural phospholipids present in \u003Cstrong>Natu-B4® are associated with the activation of metabolic\u003C\u002Fstrong> pathways related to PPAR-α (Peroxisome Proliferator-Activated Receptors), central regulators of fatty acid \u003Cstrong>metabolism and energy utilization\u003C\u002Fstrong>.  \u003C\u002Fp>\n\n\n\n\u003Cp>This metabolic approach differentiates \u003Cstrong>Natu-B4®\u003C\u002Fstrong> from conventional approaches, positioning it far beyond an\u003Cstrong> herbal choline\u003C\u002Fstrong>, but also as a natural \u003Cstrong>modulator of energy metabolism\u003C\u002Fstrong>, with consistent effects on nutrient utilization efficiency. \u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-in-nbsp-which-species-has-the-effectiveness-of-natu-b4-been-proven-nbsp\">\u003Cstrong>In which species has the effectiveness of Natu-B4® been proven?\u003C\u002Fstrong> \u003C\u002Fh2>\n\n\n\n\u003Cp>Over more than two decades, studies conducted with Natu-B4® demonstrate its applicability in different production systems: \u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Poultry: \u003C\u002Fstrong>studies indicate that Natu-B4® can be used as an alternative to choline chloride, with beneficial effects observed on production parameters.\u003Cstrong> \u003C\u002Fstrong> \u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Swine: \u003C\u002Fstrong>available data point to an association with energy use efficiency and growth profile. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Ruminants:\u003C\u002Fstrong> the product’s plant matrix is resistant to ruminal degradation, allowing metabolic effects after the rumen. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Pets: \u003C\u002Fstrong>nutrigenomics studies described in technical materials indicate modulation of metabolic pathways associated with lipid and energy metabolism. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-technological-stability-quality-and-safety-nbsp\">\u003Cstrong>Technological stability, quality, and safety\u003C\u002Fstrong> \u003C\u002Fh2>\n\n\n\n\u003Cp>In addition to its \u003Cstrong>metabolic performance, Natu-B4®\u003C\u002Fstrong> offers significant technological advantages. Because it is integrated into the plant matrix, its active compounds demonstrate high stability, do not interact negatively with vitamins or pigments, and maintain their integrity even under adverse temperature and humidity conditions.  \u003C\u002Fp>\n\n\n\n\u003Cp>Nuproxa adopts rigorous sanitation processes, such as gamma irradiation or organic acid treatments, ensuring low levels of microbiological contamination. The entire product line is \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Ffami-qs-quality\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">FAMI-QS certified\u003C\u002Fa>, in addition to ISO 9001, 14001, and 18001 certifications, ensuring traceability, quality, and environmental commitment. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\" id=\"h-technical-nbsp-expertise-nbsp-as-part-of-the-solution-nbsp-nbsp\">\u003Cstrong>Technical expertise as part of the solution \u003C\u002Fstrong> \u003C\u002Fh3>\n\n\n\n\u003Cp>\u003Cstrong>Polyherbal formulations \u003C\u002Fstrong>require in-depth knowledge of raw materials, harvesting, processing, and the correct combination of plants. With over two decades of experience, Nuproxa has consolidated a technical and after-sales support model based on scientific documentation, consistent production, and close customer follow-up.  \u003C\u002Fp>\n\n\n\n\u003Cp>This set of factors reinforces that Natu-B4® is a nutritional solution built on applied knowledge and continuous validation. \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\" id=\"h-conclusion-nbsp\">\u003Cstrong>Conclusion\u003C\u002Fstrong> \u003C\u002Fh3>\n\n\n\n\u003Cp>After 22 years of research, validation, and practical application, \u003Cstrong>Natu-B4®\u003C\u002Fstrong> has established itself as a benchmark in natural choline for animal nutrition. Its unique selling point goes beyond its plant origin and is reinforced by scientific proof of its mode of action, the robustness of its technical dossier, and the efficiency of its results.  \u003C\u002Fp>\n\n\n\n\u003Cp>In a scenario where innovation needs to be supported by evidence, Natu-B4® represents a mature, validated solution that is aligned with the current demands of animal production.  \u003C\u002Fp>\n\n\n\n\u003Ch3 class=\"wp-block-heading\" id=\"h-want-nbsp-to-know-more-about-the-benefits-of-natu-b4-for-nbsp-your-animal-nbsp-production-nbsp\">\u003Cstrong>Want to know more about the benefits of Natu-B4® for your animal production?\u003C\u002Fstrong> \u003C\u002Fh3>\n\n\n\n\u003Cp>Visit the page for the market-leading solution that has 22 years of scientific validation: \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fproducts\u002Fnatu-b4\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fproducts\u002Fnatu-b4\u002F\u003C\u002Fa>\u003Cstrong>\u003Cem>\u003C\u002Fem>\u003C\u002Fstrong> \u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>\u003Cem>Content developed from technical and scientific materials from Nuproxa\u003C\u002Fem>\u003C\u002Fstrong> \u003C\u002Fp>\n","Natu-B4®: 22 years of innovation in natural choline with scientific validation - Nuproxa Switzerland Ltd","Discover how Natu-B4®, with more than 22 years of scientific validation, has become a benchmark in natural choline for animal nutrition.",{"id":166,"filename":167,"path":168,"url":169,"alt_text":13,"title":13,"width":20,"height":21,"webp_url":170,"optimized_url":170,"thumbnail_url":171,"srcset":172,"srcset_webp":173,"responsive_images":174,"processing_status":34},773,"HEADER (12).png","assets\u002F2026\u002F05\u002Fheader-12-6a1879af88814.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-small.png 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-medium.png 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-large.png 1200w, 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1728w",{"thumbnail":171,"thumbnail_webp":175,"small":176,"small_webp":177,"medium":178,"medium_webp":179,"large":180,"large_webp":181},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-thumbnail.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-small.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-small.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-medium.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-medium.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-large.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F05\u002Fheader-12-6a1879af88814-large.webp",{"id":183,"filename":184,"path":185,"url":186,"alt_text":187,"title":188,"width":97,"height":98,"webp_url":189,"optimized_url":189,"thumbnail_url":190,"srcset":191,"srcset_webp":192,"responsive_images":193,"processing_status":34},494,"SM09_Thumb_350x250.png","assets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456.png","Nuproxa thumbnail poultry swine and cattle with chart performance in animal nutrition","Natu-B4®: 22 years of innovation in natural choline with scientific validation (thumb)","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456.png 350w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456.webp 350w",{"thumbnail":190,"thumbnail_webp":194},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F681b9520-92ea-4a27-9591-1bd6bb043456-thumbnail.webp","2026-02-05T16:17:26+00:00",{"id":52,"name":53,"slug":54,"description":13},[198],{"id":52,"name":53,"slug":54,"description":13},[],{"id":201,"title":202,"slug":203,"alternate_slugs":204,"summary":205,"content":206,"meta_title":207,"meta_description":208,"focus_keyword":13,"featured_image":209,"thumbnail_image":227,"published_at":240,"category":241,"categories":245,"tags":248},43,"Why reconsider the use of choline chloride in animal nutrition?","choline-chloride-reconsider-use",{"en":203},"In this technical guide developed by Nuproxa, we explore lesser-discussed aspects of choline chloride usage in animal nutrition, as well as its direct impact on productive performance and metabolic efficiency in animals.  What exactly is choline? Choline, chemically known as 2-hydroxyethyltrimethylammonium, is a colorless quaternary ammonium salt, highly soluble in water and alcohol (Sigma-Aldrich, 2001; […]","\n\u003Cp>In this technical guide developed by \u003Cstrong>Nuproxa\u003C\u002Fstrong>, we explore lesser-discussed aspects of choline chloride usage in animal nutrition, as well as its direct impact on \u003Cstrong>productive performance\u003C\u002Fstrong> and \u003Cstrong>metabolic efficiency\u003C\u002Fstrong> in animals. \u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-what-exactly-is-choline\">\u003Cstrong>What exactly is choline?\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>\u003Cstrong>Choline\u003C\u002Fstrong>, chemically known as \u003Cstrong>2-hydroxyethyltrimethylammonium\u003C\u002Fstrong>, is a colorless quaternary ammonium salt, highly soluble in water and alcohol (Sigma-Aldrich, 2001; Farina et al., 2014).\u003C\u002Fp>\n\n\n\n\u003Cp>While some researchers have traditionally classified choline as a B-complex vitamin, it does not meet all classical criteria for this group. Unlike other vitamins, it \u003Cstrong>does not function as a coenzyme\u003C\u002Fstrong>, its requirements are significantly higher (in grams, not micrograms), and it does not fit the standard definition of a vitamin: an essential compound synthesized endogenously and acting as an enzymatic cofactor (McDowell, 1989).\u003C\u002Fp>\n\n\n\n\u003Cp>Functionally, choline plays \u003Cstrong>crucial structural and metabolic roles\u003C\u002Fstrong>: it participates in the formation of membrane phospholipids (e.g., phosphatidylcholine), in synaptic transmission through acetylcholine, in the export of hepatic lipids, and in methylation processes via its conversion to betaine (Zeisel & Blusztajn, 1994; EFSA, 2011).\u003C\u002Fp>\n\n\n\n\u003Cp>Although many animals can synthesize sufficient amounts of choline under maintenance conditions, this capacity is often \u003Cstrong>insufficient under high production demands\u003C\u002Fstrong>, such as in rapidly growing poultry and swine with high reproductive efficiency. In these cases, \u003Cstrong>dietary supplementation becomes essential\u003C\u002Fstrong> (NRC, 1987; EFSA FEEDAP, 2011).\u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-forms-of-choline-in-food-and-their-bioavailability\">\u003Cstrong>Forms of choline in food and their bioavailability\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>Choline is foundin multiple \u003Cstrong>chemical forms in food\u003C\u002Fstrong>, such as phosphatidylcholine and free choline, which directly influences its \u003Cstrong>absorption, metabolism, and bioavailability\u003C\u002Fstrong>. According to Zeisel et al. (2003), these forms include:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Free choline\u003C\u002Fli>\n\n\n\n\u003Cli>Glycerophosphocholine\u003C\u002Fli>\n\n\n\n\u003Cli>Phosphocholine\u003C\u002Fli>\n\n\n\n\u003Cli>Phosphatidylcholine\u003C\u002Fli>\n\n\n\n\u003Cli>Sphingomyelin\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>These can also be classified by solubility (Zeisel, 2006):\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Lipid-soluble\u003C\u002Fstrong>: phosphatidylcholine (the main dietary form) and sphingomyelin\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Water-soluble\u003C\u002Fstrong>: free choline, phosphocholine, and glycerophosphocholine\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>This structural diversity complicates \u003Cstrong>quantitative analysis\u003C\u002Fstrong>, as some lab methods do not effectively extract or detect all choline forms. Furthermore, \u003Cstrong>not all forms are absorbed or metabolized equally\u003C\u002Fstrong>, making nutritional evaluation more complex.\u003C\u002Fp>\n\n\n\n\u003Cp>A study by Cheng et al. (1996) in rats found significant differences in the distribution of radiolabelled choline esters in tissues like the gastrointestinal tract and liver, indicating \u003Cstrong>variation in bioavailability depending on the ester form\u003C\u002Fstrong>.\u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-a-brief-history-of-choline-in-animal-nutrition\">\u003Cstrong>A brief history of choline in animal nutrition\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>Choline was first identified in 1847 by \u003Cstrong>Gobley\u003C\u002Fstrong>, who discovered it in egg yolk in the form of phosphatidylcholine—coining the term “lecithin.” Later, \u003Cstrong>Strecker\u003C\u002Fstrong> isolated choline from pig bile in 1849, followed by \u003Cstrong>von Babo and Hirschbrunn\u003C\u002Fstrong> who extracted it from white mustard seeds in 1852 (McDowell, 2000).\u003C\u002Fp>\n\n\n\n\u003Cp>Its nutritional importance in animals became clear in the mid-20th century. In 1940, \u003Cstrong>Jukes\u003C\u002Fstrong> demonstrated that a choline-deficient diet caused \u003Cstrong>growth retardation and perosis\u003C\u002Fstrong> in poultry—a condition marked by swollen metatarsal joints, hemorrhages, skin discoloration, and leg deformities (Titus, 1932).\u003C\u002Fp>\n\n\n\n\u003Cp>Choline deficiencies were later documented in \u003Cstrong>hamsters, calves, rabbits, and guinea pigs\u003C\u002Fstrong>, and its \u003Cstrong>preventive role in piglet leg weakness syndrome\u003C\u002Fstrong> was confirmed (McDowell, 2000).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Quillin et al. (1961)\u003C\u002Fstrong> also revealed an \u003Cstrong>inverse relationship between dietary choline and methionine\u003C\u002Fstrong> in broiler diets: lower choline levels required higher methionine supplementation to maintain weight gain. This is likely due to their \u003Cstrong>shared function as methyl donors\u003C\u002Fstrong>.\u003C\u002Fp>\n\n\n\n\u003Cp>Subsequent studies (Derilo & Balnave, 1980; Miles et al., 1983; Pourreza & Smith, 1988) suggest that \u003Cstrong>higher choline levels\u003C\u002Fstrong> may also increase the \u003Cstrong>requirement for sulfur-containing amino acids\u003C\u002Fstrong>, demonstrating a complex metabolic interaction.\u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-key-functions-of-choline-in-animal-nutrition\">\u003Cstrong>Key functions of choline in animal nutrition\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>Choline’s functions can be categorized into two main groups:\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>1. Metabolic precursor function\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Choline is a precursor to several essential compounds:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Sphingomyelin\u003C\u002Fstrong>: structural component of cell membranes, especially in the \u003Cstrong>myelin sheath\u003C\u002Fstrong> surrounding nerve axons\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Acetylcholine\u003C\u002Fstrong>: crucial neurotransmitter in nerve signal transmission\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Phosphatidylcholine\u003C\u002Fstrong>: major membrane phospholipid, critical for \u003Cstrong>cell integrity\u003C\u002Fstrong>\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Betaine\u003C\u002Fstrong>: important \u003Cstrong>methyl donor\u003C\u002Fstrong> in methionine synthesis and \u003Cstrong>homocysteine regulation\u003C\u002Fstrong>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>These roles underscore choline’s importance in \u003Cstrong>neurological, hepatic, lipid, and epigenetic functions\u003C\u002Fstrong>.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>2. Indirect regulatory function\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>Through its role in \u003Cstrong>phosphatidylcholine synthesis\u003C\u002Fstrong>, choline indirectly regulates:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Energy metabolism\u003C\u002Fstrong>, enhancing nutrient utilization\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Lipid export from the liver\u003C\u002Fstrong>, helping prevent hepatic fat accumulation (steatosis)\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Fat digestion and absorption\u003C\u002Fstrong>, through bile and lipoprotein production\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-current-choline-requirements-in-production-animals\">\u003Cbr>\u003Cstrong>Current choline requirements in production animals \u003C\u002Fstrong>\u003Cstrong>\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>Despite its importance, most official choline requirement references for livestock are \u003Cstrong>based on older studies\u003C\u002Fstrong> from the 1980s–1990s, when animals had \u003Cstrong>lower growth rates and feed efficiency\u003C\u002Fstrong>, limiting their relevance for modern genetics.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Broiler chicken requirements\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>According to the \u003Cstrong>NRC (1994)\u003C\u002Fstrong>:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>1,300 mg\u002Fkg\u003C\u002Fstrong> from 1 to 21 days of age\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>1,000 mg\u002Fkg\u003C\u002Fstrong> up to 6 weeks of age\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>Recent work by \u003Cstrong>Lima (2012)\u003C\u002Fstrong> estimated choline requirements between \u003Cstrong>1,013 and 1,232 mg\u002Fkg\u003C\u002Fstrong> during the starter phase of broilers.\u003C\u002Fp>\n\n\n\n\u003Cp>Importantly, these values account for both \u003Cstrong>naturally occurring choline\u003C\u002Fstrong> in ingredients and \u003Cstrong>dietary supplementation\u003C\u002Fstrong>, making them \u003Cstrong>practical references\u003C\u002Fstrong> for modern nutritionists.\u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-choline-content-and-sources-in-common-poultry-feed-ingredients\">\u003Cstrong>Choline content and sources in common poultry feed ingredients\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>Despite Choline concentration in feed ingredients \u003Cstrong>varies widely\u003C\u002Fstrong>, depending on their origin, composition, and lipid content. \u003Cstrong>Table 1\u003C\u002Fstrong> (adapted from Farina et al., 2014) provides an estimate of choline levels in commonly used poultry feed ingredients. It’s important to note that \u003Cstrong>analytical discrepancies\u003C\u002Fstrong> exist due to chemical diversity, processing, and lab techniques.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Table 1.\u003C\u002Fstrong> Estimated choline content of common ingredients in poultry nutrition (adapted from Farina et al., 2014)\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg src=\"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F1d3cd2e0-74b0-4c8d-be4a-7db81bbc0485.webp\" srcset=\"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F1d3cd2e0-74b0-4c8d-be4a-7db81bbc0485-small.webp 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F1d3cd2e0-74b0-4c8d-be4a-7db81bbc0485.webp 418w\" alt=\"Blog inline image\" width=\"418\" height=\"393\" loading=\"lazy\">\u003C\u002Ffigure>\n\n\n\n\u003Cp>Animal-derived ingredients, particularly those rich in phospholipids such as offal, egg yolk, and fatty tissues, are typically higher in choline compared to plant-based sources (Engel, 1943).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Kettunen et al. (2001)\u003C\u002Fstrong> demonstrated that in poultry meat, most choline is found in \u003Cstrong>fatty tissue\u003C\u002Fstrong>, primarily as phosphatidylcholine, reinforcing the \u003Cstrong>link between lipid content and choline availability\u003C\u002Fstrong>.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Offal vs. muscle\u003C\u002Fstrong>\u003Cbr>\u003Cstrong>Offal\u003C\u002Fstrong> (e.g., liver, heart, kidneys) contains \u003Cstrong>more choline\u003C\u002Fstrong> than skeletal muscle, which shows little variability across mammalian species (Engel, 1943). This information is valuable for both commercial formulations and \u003Cstrong>functional feed strategies\u003C\u002Fstrong>.\u003C\u002Fp>\n\n\n\n\u003Cp>A comparison of choline content in different animal and plant-based foods is presented in Table 2, adapted from Glade et al. (2019) and Wiedeman et al. (2018).\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Table 2.\u003C\u002Fstrong> Estimated choline content of common ingredients in poultry nutrition (adapted from Farina et al., 2014)\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg src=\"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002F7bb95efe-cf57-4d9f-bd76-19e3e98662f0.webp\" srcset=\"\" alt=\"Blog inline image\" width=\"300\" height=\"381\" loading=\"lazy\">\u003C\u002Ffigure>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-practical-use-of-choline-chloride-as-a-nutritional-supplement\">\u003Cstrong>Practical use of choline chloride as a nutritional supplement\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>\u003Cstrong>Choline chloride (CC)\u003C\u002Fstrong> is a widely used synthetic additive in animal nutrition, manufactured from \u003Cstrong>chloroethanol\u003C\u002Fstrong> and \u003Cstrong>trimethylamine (TMA)\u003C\u002Fstrong>, using \u003Cstrong>ethylene oxide\u003C\u002Fstrong> as a catalyst. By-products like \u003Cstrong>residual TMA and ethylene glycol\u003C\u002Fstrong> must be carefully controlled to ensure product safety and quality.\u003C\u002Fp>\n\n\n\n\u003Cp>In general, animal feeds are rich sources of choline, and its concentration is related to the phospholipid content (Engel, 1943). For example, Kettunen et al. (2001) demonstrated that most of the choline is associated with the adipose tissue of chicken meat, i.e., associated with phosphatidylcholine. \u003Cstrong>\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Ch2 class=\"wp-block-heading\" id=\"h-issues-related-to-trimethylamine-tma-content\">\u003Cstrong>Issues related to trimethylamine (TMA) content\u003C\u002Fstrong>\u003C\u002Fh2>\n\n\n\n\u003Cp>TMA residues are often listed in choline chloride \u003Cstrong>certificates of analysis\u003C\u002Fstrong>. Feed manufacturers generally accept levels below \u003Cstrong>300 ppm\u003C\u002Fstrong>, as higher concentrations are linked to the compound’s \u003Cstrong>fishy odor\u003C\u002Fstrong> and potential toxicity.\u003C\u002Fp>\n\n\n\n\u003Cp>Moreover, TMA can also be \u003Cstrong>formed in the gut\u003C\u002Fstrong> via microbial fermentation of \u003Cstrong>unabsorbed choline\u003C\u002Fstrong>, further increasing animal exposure. Studies show that up to \u003Cstrong>two-thirds of supplemented choline chloride may be lost as TMA\u003C\u002Fstrong> before absorption—compromising efficacy and increasing toxicological risk.\u003C\u002Fp>\n\n\n\n\u003Cp>These issues present \u003Cstrong>technical and health-related challenges\u003C\u002Fstrong> when formulating choline sources for high-efficiency production systems.\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Coming next…\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>In the second part of this article, we will explore other critical issues related to choline chloride use, including:\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>\u003Cstrong>Risks of excessive dietary chloride\u003C\u002Fstrong>\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Vitamin losses in premixes\u003C\u002Fstrong>\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Hygroscopicity and processing challenges\u003C\u002Fstrong>\u003C\u002Fli>\n\n\n\n\u003Cli>\u003Cstrong>Potential adulteration of commercial CC sources\u003C\u002Fstrong>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cp>Stay tuned! This information can help you make \u003Cstrong>safer and more efficient decisions\u003C\u002Fstrong> in animal nutrition management. Don’t miss it!\u003C\u002Fp>\n\n\n\n\u003Cp>\u003Cstrong>Bibliography\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Cheng, W. L., Holmes-McNary, M. Q., Mar, M. H., Lien, E. L., & Zeisel, S. H. (1996). Bioavailability of choline and choline esters from milk in rat pups. Journal of Nutrition, 126(6), 1447–1451. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002F126.6.1447\">https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002F126.6.1447\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Derilo, L. A., & Balnave, D. (1980). The methionine–choline relationship in chickens fed diets low in total sulfur amino acids. British Poultry Science, 21(2), 145–153.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>EFSA FEEDAP Panel. (2011). Scientific Opinion on the safety and efficacy of choline chloride for all animal species. EFSA Journal, 9(10), 2353. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2011.2353\">https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2011.2353\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Engel, R. W. (1943). The distribution of choline and betaine in animal and plant tissues. Journal of Biological Chemistry, 150(1), 211–217.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Farina, G., Anni, A., & Reginato, P. (2014). Choline in animal nutrition: biological functions and practical applications.\u003C\u002Fli>\n\n\n\n\u003Cli>Glade, M. J., Smith, K., & Kuennen, R. W. (2019). Nutritional perspectives on choline: History, requirements, and impact on health. Journal of Nutrition and Metabolism, Article ID 4050656.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Kettunen, H., Peuranen, S., & Tiihonen, K. (2001). Betaine aids in adaptation of chicks to high ambient temperature. Poultry Science, 80(5), 619–622.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Li, T., et al. (2011). \u003Cem>Choline and betaine metabolism: roles in health and disease\u003C\u002Fem>. Current Opinion in Clinical Nutrition & Metabolic Care, 14(6), 593–598. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCO.0b013e32834b4d6f\">https:\u002F\u002Fdoi.org\u002F10.1097\u002FMCO.0b013e32834b4d6f\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Lima, M. B. (2012). Requerimentos de colina para frangos de corte na fase inicial. Dissertação de Mestrado, Universidade Federal de Viçosa, Brasil.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>McDowell, L. R. (1989). Vitamins in animal nutrition: Comparative aspects to human nutrition. Academic Press.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>McDowell, L. R. (2000). Vitamins in Animal and Human Nutrition (2nd ed.). Wiley-Blackwell.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Miles, R. D., Butcher, G. D., Henry, P. R., & Littell, R. C. (1983). The influence of choline and methionine on liver lipid accumulation in turkeys. Poultry Science, 62(2), 255–261.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>National Research Council (NRC). (1987). Nutrient Requirements of Swine (9th rev. ed.). National Academies Press.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>National Research Council (NRC). (1994). Nutrient Requirements of Poultry (9th Rev. Ed.). National Academies Press.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Pourreza, J., & Smith, J. L. (1988). The relationship between choline and methionine in laying hens. Poultry Science, 67(5), 780–783.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Quillin, E. C., Nesheim, M. C., & Scott, M. L. (1961). The relationship between choline and methionine in the nutrition of chicks. Journal of Nutrition, 73, 103–109.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Sigma-Aldrich. (2001). Product information sheet: Choline chloride.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Wiedeman, A. M., Barr, S. I., Green, T. J., & Xu, Z. (2018). Food sources and modifiable determinants of choline intake in a Canadian population. British Journal of Nutrition, 120(3), 282–290. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1017\u002FS0007114518001116\">https:\u002F\u002Fdoi.org\u002F10.1017\u002FS0007114518001116\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Zeisel SH. Requirements in Adults. 2006;(26):229–50.\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Zeisel, S. H., & Blusztajn, J. K. (1994). Choline and human nutrition. Annual Review of Nutrition, 14(1), 269–296. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1146\u002Fannurev.nu.14.070194.001413\">https:\u002F\u002Fdoi.org\u002F10.1146\u002Fannurev.nu.14.070194.001413\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Zeisel, S. H., & da Costa, K. A. (2009). Choline: An essential nutrient for public health. Nutrition Reviews, 67(11), 615–623. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1753-4887.2009.00246.x\">https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1753-4887.2009.00246.x\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n\n\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Zeisel, S. H., & Warrier, M. (2017). \u003Cem>Trimethylamine N-oxide, the microbiome, and heart and kidney disease\u003C\u002Fem>. Annual Review of Nutrition, 37, 157–181. \u003Ca href=\"https:\u002F\u002Fdoi.org\u002F10.1146\u002Fannurev-nutr-071816-064732\">https:\u002F\u002Fdoi.org\u002F10.1146\u002Fannurev-nutr-071816-064732\u003C\u002Fa>\u003C\u002Fli>\n\u003C\u002Ful>\n","Choline chloride in animal nutrition: Why reconsider?","Find out why choline chloride may not be the best choice in modern animal nutrition.",{"id":210,"filename":211,"path":212,"url":213,"alt_text":214,"title":13,"width":20,"height":21,"webp_url":215,"optimized_url":215,"thumbnail_url":216,"srcset":217,"srcset_webp":218,"responsive_images":219,"processing_status":34},755,"HEADER (2).png","assets\u002F2026\u002F04\u002Fheader-2-69e2692661a85.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85.png","Modern poultry house header with feeders, Nuproxa poultry production animal nutrition","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-small.png 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-medium.png 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-large.png 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85.png 1728w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-small.webp 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-medium.webp 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-large.webp 1200w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85.webp 1728w",{"large":220,"small":221,"medium":222,"thumbnail":216,"large_webp":223,"small_webp":224,"medium_webp":225,"thumbnail_webp":226},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-large.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-small.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-medium.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-large.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-small.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-medium.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F04\u002Fheader-2-69e2692661a85-thumbnail.webp",{"id":228,"filename":229,"path":230,"url":231,"alt_text":232,"title":233,"width":97,"height":98,"webp_url":234,"optimized_url":234,"thumbnail_url":235,"srcset":236,"srcset_webp":237,"responsive_images":238,"processing_status":34},513,"02_Blog_posts-thumb_1.jpg","assets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852.jpg","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852.jpg","Thumbnail grain silos feed industry and animal nutrition Nuproxa ingredients","Why reconsider the use of choline chloride in animal nutrition? (thumb)","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852-thumbnail.jpg","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852-thumbnail.jpg 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852.jpg 350w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852.webp 350w",{"thumbnail":235,"thumbnail_webp":239},"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fd25d6dec-c1fa-45d7-87f1-578c0e537852-thumbnail.webp","2025-04-29T17:37:30+00:00",{"id":242,"name":243,"slug":244,"description":13},42,"News","news",[246,247],{"id":242,"name":243,"slug":244,"description":13},{"id":52,"name":53,"slug":54,"description":13},[],{"data":250},[251,304,314,324,349,359],{"id":252,"title":253,"slug":254,"alternate_slugs":255,"summary":258,"content":259,"meta_title":260,"meta_description":261,"focus_keyword":54,"featured_image":262,"thumbnail_image":280,"published_at":292,"category":293,"categories":294,"tags":303},133,"Who makes up the starting lineup of intelligent nutrition?","nuproxa-selection",{"pt":256,"en":254,"latam":257},"selecao-nuproxa","seleccion-nuproxa","The article presents Nuproxa's portfolio as a \"team\" of solutions and technical programs for animal nutrition, using a football team metaphor in which each product plays a specific role. It details the roles of NuxaSan, LivoLiv, Natu-B4, NuxaFen, C-Power, Neotegra, iNuxA-B4, and iNuxA-VC, covering metabolism, gut health, antioxidant protection, stress response, liver health, and aquaculture. It then describes the technical support programs (NAP Swine, NAP Poultry, and GHP), which turn field data into decisions to improve performance, profitability, and sustainability across poultry, swine, ruminant, fish, and shrimp production.","\u003Cp>\u003Cem>The Nuproxa Team and the technical support behind results in animal production.\u003C\u002Fem>\u003C\u002Fp>\u003Cp>In \u003Cstrong>animal production\u003C\u002Fstrong>, no consistent result comes from a single play. Just like in a great team, every role matters. Some players hold the defense, some organize the strategy, some accelerate performance, some respond to moments of pressure, and some help maintain energy efficiency.\u003C\u002Fp>\u003Cp>\u003Cstrong>This is the logic behind the Nuproxa Team\u003C\u002Fstrong>: a portfolio of naturally intelligent solutions and specialized technical programs developed to support different nutritional and production challenges.\u003C\u002Fp>\u003Cp>We are not talking only about products, but about a true team that brings together applied science, field experience, technical validation, and specialized support to help producers, nutritionists, formulators, and partners make more efficient, reliable, and profitable decisions.\u003C\u002Fp>\u003Ch2>A complete lineup for different animal production challenges\u003C\u002Fh2>\u003Cp>Poultry, swine, ruminant, fish, and shrimp production face challenges related to metabolism, gut health, stress, feed efficiency, quality, profitability, and sustainability. That is why relying on a single solution is not always enough.\u003C\u002Fp>\u003Cp>\u003Cstrong>It is necessary to build a consistent strategy rather than respond to challenges one at a time.\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>In the Nuproxa Team, every starter has a specific role within this nutritional strategy. \u003Cstrong>And they all share a common goal\u003C\u002Fstrong>: to contribute to smarter programs aligned with the real needs of each species and production system.\u003C\u002Fp>\u003Ch2>NuxaSan™: the defense for challenging moments\u003C\u002Fh2>\u003Cp>Every team needs a defense prepared to respond during moments of greater pressure.\u003C\u002Fp>\u003Cp>\u003Cstrong>In the Nuproxa Team, NuxaSan™ plays this role\u003C\u002Fstrong> by contributing as a productive performance enhancer in situations associated with protozoal challenges, supporting more efficient nutritional programs.\u003C\u002Fp>\u003Cp>Its role is especially relevant when the objective is to sustain productive response and strengthen efficiency-focused strategies through phytogenic compounds recognized for helping maintain the balance of the intestinal microbiota.\u003C\u002Fp>\u003Ch2>\u003Cstrong>LivoLiv Meta™: the team’s metabolic accelerator\u003C\u002Fstrong>\u003C\u002Fh2>\u003Cp>In a high-performing team, energy makes a difference.\u003C\u002Fp>\u003Cp>\u003Cstrong>LivoLiv Meta™ joins this lineup as a natural metabolic accelerator,\u003C\u002Fstrong> developed to support liver function, promote nutrient utilization, and optimize productive performance in poultry, swine, and ruminants.\u003C\u002Fp>\u003Cp>Its action contributes to liver health, metabolic response, and nutritional efficiency, all of which are fundamental in intensive production systems. When metabolism performs better, the nutritional strategy gains greater strength to transform formulation into results.\u003C\u002Fp>\u003Ch2>Natu-B4®: efficiency to turn energy into results\u003C\u002Fh2>\u003Cp>In a high-performing team, making the most of every resource makes all the difference.\u003C\u002Fp>\u003Cp>In the Nuproxa Team, \u003Cstrong>Natu-B4® contributes to this goal by acting as a natural modulator of energy metabolism\u003C\u002Fstrong>, supporting the efficient utilization of nutrients and energy by animals.\u003C\u002Fp>\u003Cp>More than a natural alternative to choline chloride, Natu-B4® supports nutritional programs focused on metabolic efficiency and productive performance, helping transform nutrition into consistent results.\u003C\u002Fp>\u003Ch2>NuxaFen™: the antioxidant protection specialist\u003C\u002Fh2>\u003Cp>Every team needs players capable of maintaining consistency even under challenging conditions.\u003C\u002Fp>\u003Cp>\u003Cstrong>NuxaFen™ harnesses the natural antioxidant potential of polyphenols\u003C\u002Fstrong> to support productivity, performance, and animal well-being. Its action helps reduce the effects of oxidative stress. In practice, it is a starter that contributes to greater formulation flexibility, economic efficiency, and support for the quality of animal-derived products.\u003C\u002Fp>\u003Ch2>C-Power™: the strength of the team in moments of pressure\u003C\u002Fh2>\u003Cp>In intensive production systems, moments of pressure are part of the routine.\u003C\u002Fp>\u003Cp>Heat, stocking density, metabolic challenges, management practices, and other factors can impact animal well-being, productivity, and efficiency. It is in this scenario that C-Power™ stands out.\u003C\u002Fp>\u003Cp>\u003Cstrong>As an anti-stress polyherbal complex\u003C\u002Fstrong> with natural antioxidant action and high bioavailability, C-Power™ was developed to help animals respond better to uncontrollable stress factors, supporting performance, feed efficiency, and productive response.\u003C\u002Fp>\u003Ch2>iNuxA-B4®: more than choline, a strategy for efficiency in aquaculture\u003C\u002Fh2>\u003Cp>Some starters stand out because they go beyond their traditional role.\u003C\u002Fp>\u003Cp>\u003Cstrong>iNuxA-B4® is an innovative solution for feed and premix formulation\u003C\u002Fstrong>, especially designed for aquaculture. More than a natural source of choline, it offers a 100% natural alternative to choline chloride in fish and shrimp diets.\u003C\u002Fp>\u003Cp>Its value proposition combines important formulation advantages, such as stability, lower hygroscopicity, low inclusion rates, and better use of space in premixes and feeds.\u003C\u002Fp>\u003Ch2>iNuxA-VC®: antioxidant support and efficiency for aquaculture\u003C\u002Fh2>\u003Cp>In aquaculture, performance also depends on adequate nutritional support for health, antioxidant response, and animal resilience.\u003C\u002Fp>\u003Cp>\u003Cstrong>iNuxA-VC® is a natural and highly bioavailable analog form of vitamin C\u003C\u002Fstrong>, developed for fish and shrimp. Its purpose is to replace monophosphate vitamin C, offering greater stability, high bioavailability, and additional benefits for health and performance.\u003C\u002Fp>\u003Cp>Among its key advantages are extrusion resistance, stability at high temperatures, low inclusion rates per ton of feed, and support for immune response, protection against oxidative stress, and regeneration processes.\u003C\u002Fp>\u003Ch2>The support that strengthens the team\u003C\u002Fh2>\u003Cp>\u003Cstrong>A great lineup needs more than just good starters.\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>It also needs technical insight, follow-up, data, and strategies that can be applied to the reality of each production system. This is where Nuproxa's programs come into play.\u003C\u002Fp>\u003Cp>They work as the support that strengthens the team: helping transform field information into more precise decisions and nutritional programs that are better aligned with production goals.\u003C\u002Fp>\u003Ch2>Technical Assistance Program for more efficient swine production\u003C\u002Fh2>\u003Cp>\u003Cstrong>The \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fnap-swine\">NAP Nuproxa Assistance Program for Swine\u003C\u002Fa>\u003C\u002Fstrong> was developed to support modern swine production through technical support and nutritional follow-up.\u003C\u002Fp>\u003Cp>The program considers challenges related to management, animal welfare, health, nutrition, and sustainability, helping identify opportunities for improvement and strengthen customized intelligent nutrition programs.\u003C\u002Fp>\u003Cp>NAP Swine contributes to a more integrated view of production, with a focus on efficiency, productivity, and cost reduction.\u003C\u002Fp>\u003Ch2>Technical Assistance Program for poultry: data, performance, and applied intelligence\u003C\u002Fh2>\u003Cp>In poultry production, high performance requires technical control, continuous follow-up, and decisions based on reliable information.\u003C\u002Fp>\u003Cp>\u003Cstrong>The \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fnap-poultry\">NAP Technical Assistance Program for Poultry\u003C\u002Fa>\u003C\u002Fstrong> was created to provide specialized technical support, data analysis, monitoring of nutrition and production program performance, identification of bottlenecks, and opportunities throughout the production chain.\u003C\u002Fp>\u003Cp>Its role is to support poultry companies seeking greater profitability, zootechnical performance, and strategic production management.\u003C\u002Fp>\u003Ch2>GHP: Gut and Hepatic Health Program for maximum performance\u003C\u002Fh2>\u003Cp>\u003Cstrong>The \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002Fghp\">Gut Hepatic Health Program\u003C\u002Fa> is Nuproxa's technical-scientific program\u003C\u002Fstrong> focused on the diagnosis, monitoring, and optimization of gut and liver health, especially in broilers and other poultry production species.\u003C\u002Fp>\u003Cp>Through field evaluations, laboratory analyses, and data interpretation, GHP transforms complex information into practical decisions that support zootechnical performance, profitability, and health security.\u003C\u002Fp>\u003Cp>Its approach helps identify digestive alterations, evaluate nutritional and health programs, monitor animal response, and support more precise strategies in the field.\u003C\u002Fp>\u003Cp>\u003Cstrong>The right lineup makes a difference.\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cstrong>In modern animal production, every decision matters.\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>Choosing a solution is not just about selecting a product. It is about defining the role it will play within a broader nutritional strategy connected to the challenges of the species, the production system, and performance objectives.\u003C\u002Fp>\u003Cp>\u003Cstrong>That is why the Nuproxa Team brings together starters with complementary roles\u003C\u002Fstrong>: solutions that support metabolism, gut integrity, antioxidant support, stress response, liver health, aquaculture, and productive performance, along with technical programs that help transform data into decisions.\u003C\u002Fp>\u003Cp>\u003Cstrong>Get to know the Nuproxa Team and discover how each starter can support your nutritional strategy\u003C\u002Fstrong>: \u003Ca target=\"_blank\" rel=\"noopener noreferrer nofollow\" href=\"https:\u002F\u002Fnuproxa.ch\u002F\">https:\u002F\u002Fnuproxa.ch\u002F\u003C\u002Fa>\u003C\u002Fp>","Nuproxa Team: Intelligent Animal Nutrition Lineup","Discover the Nuproxa Team of solutions and technical programs for intelligent animal nutrition in poultry, swine, ruminants, fish, and shrimp production.",{"id":263,"filename":264,"path":265,"url":266,"alt_text":267,"title":12,"width":20,"height":21,"webp_url":268,"optimized_url":268,"thumbnail_url":269,"srcset":270,"srcset_webp":271,"responsive_images":272,"processing_status":34},786,"01KVWVSRBDB04PTG6MX42136DA.png","gallery\u002F01KVWVSRBDB04PTG6MX42136DA.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVSRBDB04PTG6MX42136DA.png","Blurred background of a football stadium with grass field and stands","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVSRBDB04PTG6MX42136DA.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVSRBDB04PTG6MX42136DA-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVSRBDB04PTG6MX42136DA-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVSRBDB04PTG6MX42136DA-small.png 400w, 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product bags in blue, green, pink, and gray on podiums on a football field, each with a five-star rating","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F.webp","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F-thumbnail.png","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F-thumbnail.png 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F.png 350w","https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F-thumbnail.webp 150w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fgallery\u002F01KVWVTFQ48JGBNZ5CAWZ2D34F.webp 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protector vs hepatic modulator in poultry: understand the differences","hepatic-protector-hepatic-modulator-in-poultry",{"en":327},"Hepatic health in poultry production is crucial for animal welfare, productivity, and zootechnical performance. Understand the differences between hepatic protectors and modulators.","\u003Cp>\u003Cstrong>Hepatic health in poultry\u003C\u002Fstrong> production is a crucial factor to ensure animal welfare, productivity, and zootechnical performance. The liver is a multifunctional organ responsible for essential metabolic processes, detoxification of substances, and support of the immune system. Therefore, preserving its function is a priority in intensive production systems. \u003C\u002Fp>\n\n\u003Cp>In this context, different products have been developed to help maintain liver function under optimal conditions and prevent disorders. Among them, two groups stand out: \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Hepatic protectors; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Hepatic modulators. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>Although both aim to support liver health, their approaches are different. Understanding these differences is essential for a strategic use in animal nutrition, according to the production phase and the challenges faced by the birds.  \u003Cbr> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>What is a hepatic protector?\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Hepatic protectors\u003C\u002Fstrong> are substances designed to prevent liver damage and protect the functional integrity of the liver against challenges such as: \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Environmental toxins; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Feed contaminants; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Mycotoxins. \u003Cbr> \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>\u003Cstrong>These products usually contain a combination of:\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Vitamins (such as vitamin E); \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Minerals (such as selenium); \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Amino acids (such as methionine); \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Plants with hepatoprotective properties (such as milk thistle and artichoke). \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>\u003Cstrong>These ingredients act synergistically to:\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Strengthen liver defenses; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Improve detoxification capacity; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Reduce hepatic inflammation. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>The use of \u003Cstrong>hepatic protectors \u003C\u002Fstrong>is especially recommended during periods of rapid growth, feed transitions, vaccination, and environmental stress, providing additional support to maintain optimal liver function and reduce the incidence of diseases. \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Why is a hepatic modulator different from a hepatic protector?\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>Unlike protectors, which have a preventive role, \u003Cstrong>hepatic modulators in poultry\u003C\u002Fstrong> play a more active role in the physiological regulation of liver function. In other words, they not only contribute to protection but also help modulate liver processes, promoting more efficient function. \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>These products typically contain:\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Plant extracts (such as rosemary and turmeric); \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Prebiotics and probiotics; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Organic acids; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Oligosaccharides. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>By promoting the\u003Cstrong> balance of the intestinal microbiota\u003C\u002Fstrong>, they help improve digestion, nutrient absorption, and reduce the toxic load on the liver. \u003Cbr> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Among their physiological effects, the following stand out:\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Regulation of hepatic enzymatic activity; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Stimulation of cellular regeneration; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Reduction of hepatic inflammation. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>These mechanisms are particularly useful in situations of metabolic overload, allowing the liver to restore its optimal performance even after physiological challenges. \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Conclusion\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Hepatic protectors and modulators in poultry \u003C\u002Fstrong>are strategic allies in maintaining liver health. Each product group offers specific benefits, and their selection should consider: \u003C\u002Fp>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Management conditions; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Production phase; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Health status of the flock; \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cul class=\"wp-block-list\">\n\u003Cli>Zootechnical objectives. \u003C\u002Fli>\n\u003C\u002Ful>\n\n\u003Cp>While \u003Cstrong>hepatic protectors \u003C\u002Fstrong>mainly focus on preventing liver damage and preserving liver integrity, modulators go further by actively regulating liver function and contributing to improved intestinal health. In many cases, combining both types of products can be beneficial to maximize \u003Cstrong>poultry performance in modern production systems.\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>Want to explore this evaluation further?\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>Talk to one of our technical specialists to understand how to adapt the use to your production reality: \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcontact\u002F\" target=\"_blank\" rel=\"noreferrer noopener\">https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fcontact\u002F\u003C\u002Fa> \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>An advanced solution from Nuproxa\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>Nuproxa offers \u003Ca href=\"https:\u002F\u002Fnuproxa.ch\u002Fen\u002Fproducts\u002Flivoliv\" target=\"_blank\" rel=\"noreferrer noopener\">Livoliv 250™\u003C\u002Fa>, a polyherbal product developed based on nutrigenomics, combining a complex set of phytoactives capable of supporting the modulation and acceleration of hepatic regeneration metabolism, helping promote optimal liver functionality and improve poultry performance. \u003C\u002Fp>\n\n\u003Cp>\u003Cstrong>\u003Cem>Source:\u003C\u002Fem>\u003C\u002Fstrong> \u003C\u002Fp>\n\n\u003Cp>\u003Cem>Nuproxa technical team. \u003C\u002Fem>\u003Cem>Entendiendo las diferencias entre un protector hepático y un modulador hepático en avicultura.\u003C\u002Fem> \u003C\u002Fp>","Hepatic protector vs. hepatic modulator in poultry farming","Hepatic protector vs. hepatic modulator in poultry farming: understand the differences for a strategic use in animal nutrition.","hepatic protector poultry",{"id":210,"filename":211,"path":212,"url":213,"alt_text":214,"title":13,"width":20,"height":21,"webp_url":215,"optimized_url":215,"thumbnail_url":216,"srcset":217,"srcset_webp":218,"responsive_images":335,"processing_status":34},{"large":220,"small":221,"medium":222,"thumbnail":216,"large_webp":223,"small_webp":224,"medium_webp":225,"thumbnail_webp":226},{"id":210,"filename":211,"path":212,"url":213,"alt_text":214,"title":13,"width":20,"height":21,"webp_url":215,"optimized_url":215,"thumbnail_url":216,"srcset":217,"srcset_webp":218,"responsive_images":337,"processing_status":34},{"large":220,"small":221,"medium":222,"thumbnail":216,"large_webp":223,"small_webp":224,"medium_webp":225,"thumbnail_webp":226},"2026-03-27T20:57:19+00:00",{"id":157,"name":340,"slug":341,"description":13},"Health","health",[343,344],{"id":157,"name":340,"slug":341,"description":13},{"id":345,"name":346,"slug":347,"description":13},63,"Poultry","poultry",[],{"id":157,"title":158,"slug":159,"alternate_slugs":350,"summary":161,"content":162,"meta_title":163,"meta_description":164,"focus_keyword":13,"featured_image":351,"thumbnail_image":353,"published_at":195,"category":355,"categories":356,"tags":358},{"en":159},{"id":166,"filename":167,"path":168,"url":169,"alt_text":13,"title":13,"width":20,"height":21,"webp_url":170,"optimized_url":170,"thumbnail_url":171,"srcset":172,"srcset_webp":173,"responsive_images":352,"processing_status":34},{"thumbnail":171,"thumbnail_webp":175,"small":176,"small_webp":177,"medium":178,"medium_webp":179,"large":180,"large_webp":181},{"id":183,"filename":184,"path":185,"url":186,"alt_text":187,"title":188,"width":97,"height":98,"webp_url":189,"optimized_url":189,"thumbnail_url":190,"srcset":191,"srcset_webp":192,"responsive_images":354,"processing_status":34},{"thumbnail":190,"thumbnail_webp":194},{"id":52,"name":53,"slug":54,"description":13},[357],{"id":52,"name":53,"slug":54,"description":13},[],{"id":360,"title":361,"slug":362,"alternate_slugs":363,"summary":364,"content":365,"meta_title":366,"meta_description":367,"focus_keyword":13,"featured_image":368,"thumbnail_image":386,"published_at":388,"category":389,"categories":390,"tags":392},35,"FAMI-QS: a commitment to quality that unites Nuproxa Switzerland and its affiliates in Latin America","fami-qs-quality",{"en":362},"By Ana Paula Barp Brandt, Quality Director of the Nuproxa Group During Nuproxa Quality Week, we celebrate the values that underpin our commitment to excellence. One of the pillars of this journey is FAMI-QS certification, an international code of good practice for special ingredients for animal nutrition. At Nuproxa Switzerland, FAMI-QS implementation and certification represents […]","\n\u003Cp>\u003Cstrong>By Ana Paula Barp Brandt, Quality Director of the Nuproxa Group\u003C\u002Fstrong>\u003C\u002Fp>\n\n\n\n\u003Cp>During \u003Cstrong>Nuproxa Quality Week\u003C\u002Fstrong>, we celebrate the values that underpin our commitment to excellence. One of the pillars of this journey is \u003Cstrong>FAMI-QS certification\u003C\u002Fstrong>, an international code of good practice for special ingredients for animal nutrition.\u003C\u002Fp>\n\n\n\n\u003Cp>At Nuproxa Switzerland, \u003Cstrong>FAMI-QS\u003C\u002Fstrong> implementation and certification represents more than technical compliance—it is a clear expression of our \u003Cstrong>commitment to safety, traceability, and regulatory compliance\u003C\u002Fstrong>. And this commitment is being expanded: the Nuproxa Group is conducting a strategic project to implement and certify FAMI-QS in its affiliates in Latin America. \u003Cbr>\u003Cbr>\u003Cstrong>We already have two duly certified affiliates: Nuproxa Mexico and Nuproxa Chile.\u003C\u002Fstrong> The next affiliate is Nuproxa Colombia, which is working hard to implement a quality system in order to obtain certification.\u003C\u002Fp>\n\n\n\n\u003Cp>This move reinforces our \u003Cstrong>role as an integrated and responsible group and positions us as pioneers in the region\u003C\u002Fstrong>. Few companies of Nuproxa’s size in Latin America have adopted this international standard, which makes this initiative a competitive advantage and a concrete demonstration of our commitment to delivering differentiated products and services with safety and reliability.\u003Cbr>\u003Cbr>\u003Cstrong>According to global data, only 2% of FAMI-QS certifications are in South America\u003C\u002Fstrong>, while Asia accounts for 55% and Europe 34%. This figure highlights how limited adherence to the international standard still is in the region, \u003Cstrong>reinforcing Nuproxa’s pioneering\u003C\u002Fstrong> character and the importance of our project in raising the level of quality in the Latin American market.\u003C\u002Fp>\n\n\n\n\u003Cfigure class=\"wp-block-image size-large\">\u003Cimg src=\"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fc86ba5ec-c2a6-4203-99a0-c5734462615c.webp\" srcset=\"https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fc86ba5ec-c2a6-4203-99a0-c5734462615c-small.webp 400w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fc86ba5ec-c2a6-4203-99a0-c5734462615c-medium.webp 800w, https:\u002F\u002Fapi.nuproxa.ch\u002Fstorage\u002Fassets\u002F2026\u002F03\u002Fc86ba5ec-c2a6-4203-99a0-c5734462615c.webp 1024w\" alt=\"Blog inline image\" width=\"1024\" height=\"580\" loading=\"lazy\">\u003C\u002Ffigure>\n\n\n\n\u003Cp 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